{"id":1139,"date":"2018-03-18T09:09:08","date_gmt":"2018-03-18T08:09:08","guid":{"rendered":"http:\/\/psychotropes.info\/wordpress\/?p=1139"},"modified":"2018-04-06T16:24:43","modified_gmt":"2018-04-06T14:24:43","slug":"les-doses-equivalentes","status":"publish","type":"post","link":"https:\/\/psychotropes.info\/wordpress\/2018\/03\/les-doses-equivalentes\/","title":{"rendered":"Les doses \u00e9quivalentes"},"content":{"rendered":"<p><strong>De quoi faut-il tenir compte lors de la substitution?<\/strong><br \/>\n<strong>1. Des doses \u00e9quivalentes<\/strong><\/p>\n<p>Il faut tenir compte des diff\u00e9rences de concentration entre <strong>les benzodiaz\u00e9pines<\/strong>, c\u2019est-\u00e0-dire de leurs doses \u00e9quivalentes ou \u00e9quivalences.<\/p>\n<p>En effet, avec une certaine mol\u00e9cule, 1 mg de cette substance suffira \u00e0 produire les effets pr\u00e9vus, alors qu\u2019avec une autre mol\u00e9cule, aux m\u00eames propri\u00e9t\u00e9s, il faudra utiliser 10 mg de cette substance pour obtenir les \u201cm\u00eames effets\u201d. C\u2019est ainsi que la concentration en <a href=\"https:\/\/psychotropes.info\/wordpress\/les-psychotropes\/les-benzodiazepines\/\" target=\"_blank\" rel=\"noopener\">benzodiaz\u00e9pine <\/a>dans les solutions solides ou liquides (comprim\u00e9s, g\u00e9lules, gouttes, solutions buvables,&#8230;) peut fortement varier d\u2019un m\u00e9dicament \u00e0 l\u2019autre.<\/p>\n<p>Par exemple, il faudra utiliser un comprim\u00e9 contenant une concentration de 20 mg de diaz\u00e9pam pour obtenir les \u201cm\u00eames effets\u201d qu\u2019un comprim\u00e9 contenant une concentration de 1 mg d\u2019alprazolam.<\/p>\n<p>A noter que, comme le souligne la Prof. Ashton (cit\u00e9e par Nimmo, 2012), beaucoup de gens ont souffert parce qu&rsquo;on les avait chang\u00e9s brusquement pour une benzodiaz\u00e9pine diff\u00e9rente et moins forte parce que le m\u00e9decin n&rsquo;avait pas tenu compte du facteur important de concentration diff\u00e9rente.<\/p>\n<ul>\n<li>Tableau d\u2019\u00e9quivalences propos\u00e9 dans le <strong>Manuel Ashton<\/strong> (2012): <a href=\"http:\/\/www.benzo.org.uk\/freman\/bzcha01.htm#24\" target=\"_blank\" rel=\"noopener\">http:\/\/www.benzo.org.uk\/freman\/bzcha01.htm#24<\/a><\/li>\n<li>Retrouvez les doses \u00e9quivalentes des benzodiaz\u00e9pines dans le <strong>calculateur\/convertisseur de Jomax<\/strong> (2017) en allant dans le menu <em>Conversion<\/em>, puis en cliquant sur <em>Benzo Conversion<\/em>: <a href=\"http:\/\/psychotropes.info\/calculateur\/\">http:\/\/psychotropes.info\/calculateur\/<\/a> ou <a href=\"http:\/\/electrotracks.free.fr\/aide\/benzo_equivalence\/\" target=\"_blank\" rel=\"noopener\">http:\/\/electrotracks.free.fr\/aide\/benzo_equivalence\/<\/a><\/li>\n<li>Les \u00e9quivalences entre les benzodiaz\u00e9pines (SoutienBenzo): <a href=\"http:\/\/soutienbenzo.forumgratuit.org\/t81-conversions-equivalences-avec-les-somniferes-et-neuroleptiques-et-antidepresseurs\" target=\"_blank\" rel=\"noopener\">http:\/\/soutienbenzo.forumgratuit.org\/t81-conversions-equivalences-avec-les-somniferes-et-neuroleptiques-et-antidepresseurs<\/a><\/li>\n<li>Tableau des \u00e9quivalences et des demi-vie des benzodiaz\u00e9pines: <a href=\"https:\/\/sites.google.com\/site\/sevrageauxbenzodiazepines\/Home\/les-benzodiazepines-plus-dangereuses-qu-on-ne-le-pense\" target=\"_blank\" rel=\"noopener\">https:\/\/sites.google.com\/site\/sevrageauxbenzodiazepines\/Home\/les-benzodiazepines-plus-dangereuses-qu-on-ne-le-pense<\/a><\/li>\n<li>Liste des \u00e9quivalences des benzodiaz\u00e9pines (CBIP, 2018): <a href=\"http:\/\/www.cbip.be\/fr\/chapters\/11?frag=7476\" target=\"_blank\" rel=\"noopener\">http:\/\/www.cbip.be\/fr\/chapters\/11?frag=7476<\/a><\/li>\n<\/ul>\n<p>Attention, comme l\u2019explique la Prof. Ashton (cit\u00e9e par Nimmo, 2012), les \u00e9quivalences en concentration des benzodiaz\u00e9pines donn\u00e9es dans les tableaux d\u2019\u00e9quivalences sont approximatives et peuvent diff\u00e9rer d\u2019un individu \u00e0 l\u2019autre.<\/p>\n<p><strong>De quoi faut-il encore tenir compte lors de la substitution?<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/psychotropes.info\/wordpress\/2018\/03\/les-profils-daction-differents-des-molecules\/\">Des profils d\u2019action diff\u00e9rents des mol\u00e9cules<\/a><\/li>\n<li><a href=\"https:\/\/psychotropes.info\/wordpress\/2018\/03\/la-forme-galenique-sous-laquelle-le-medicament-est-administre\/\">De la forme gal\u00e9nique (comprim\u00e9, gouttes, g\u00e9lule, \u2026) sous laquelle le m\u00e9dicament est administr\u00e9<\/a><\/li>\n<\/ul>\n<p style=\"text-align: right;\"><a href=\"https:\/\/psychotropes.info\/wordpress\/2018\/03\/comment-proceder-a-une-substitution\/\">Comment proc\u00e9der \u00e0 une substitution?<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>De quoi faut-il tenir compte lors de la substitution? 1. Des doses \u00e9quivalentes Il faut tenir compte des diff\u00e9rences de concentration entre les benzodiaz\u00e9pines, c\u2019est-\u00e0-dire de leurs doses \u00e9quivalentes ou \u00e9quivalences. En effet, avec une certaine mol\u00e9cule, 1 mg de cette substance suffira \u00e0 produire les effets pr\u00e9vus, alors qu\u2019avec une autre mol\u00e9cule, aux m\u00eames [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[97,52,111],"tags":[19,57,72,36,101,104,112,37,58,55,54,84,77,73],"class_list":["post-1139","post","type-post","status-publish","format-standard","hentry","category-manuel-de-sevrage","category-sevrage","category-substitution","tag-antidepresseurs","tag-anxiolytique","tag-asthon","tag-benzodiazepines","tag-demi-vie","tag-dose","tag-equivalences","tag-isrs","tag-neuroleptique","tag-sevrage","tag-sevrage-lent","tag-stabilisation","tag-substitution","tag-tolerance"],"_links":{"self":[{"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/posts\/1139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/comments?post=1139"}],"version-history":[{"count":13,"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/posts\/1139\/revisions"}],"predecessor-version":[{"id":1853,"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/posts\/1139\/revisions\/1853"}],"wp:attachment":[{"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/media?parent=1139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/categories?post=1139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/psychotropes.info\/wordpress\/wp-json\/wp\/v2\/tags?post=1139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}